Figure 1. Concentration-time plots for ketamine and norketamine after oral administration of 50 mg ketamine to healthy volunteers (n = 6)
| Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc |
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Short Communication
Volume 3, Number 2, October 2013, pages 82-86
Pharmacokinetics of Ketamine and Norketamine After Oral Administration of a Liquid Formulation of Ketamine
Figure
Tables
| Parameter | Ketamine | Norketamine |
|---|---|---|
| Cmax: maximum serum concentration; Tmax: time to reach Cmax; AUC0-12: area under the serum concentration-time curve from baseline to 12 hours; T1/2: half-life; Cltot/F: total clearance; Vdss: volume of distribution at steady-state. | ||
| Cmax (ng/mL) | 29.9 ± 5.3 | 250.2 ± 28.7 |
| Tmax (hr) | 1.1 ± 0.2 | 1.6 ± 0.2 |
| AUC0→12 (ng·hr/mL) | 79.0 ± 24.0 | 1193.1 ± 159.6 |
| T1/2 (hr) | 1.1 ± 0.5 | 5.3 ± 1.1 |
| Cltot/F (L/hr) | 2,096.5 ± 1,139.7 | 40.4 ± 7.5 |
| Vdss/F (L) | 2,340.9 ± 891.9 | 226.9 ± 33.5 |
| Time (hours) | 0 | 0.25 | 0.5 | 0.75 | 1 | 1.5 | 2 | 6 | 12 |
|---|---|---|---|---|---|---|---|---|---|
| n = 6. | |||||||||
| nausea | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
| sleepy | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 0 | 0 |
| Feeling drunk | 0 | 1 | 5 | 6 | 5 | 3 | 1 | 0 | 0 |